1/7/2024 0 Comments Anti mog antibodyResults so far suggest that MOG antibodies are rare in patients with MS associated optic neuritis, and were more common in other demyelinating diseases.Īdditionally, Dr Brilot-Turville is examining the levels of MOG antibodies in the blood of patients currently undergoing immunotherapies. To date, Dr Brilot-Turville has collected blood from a number of patients and has been following their clinical symptoms. Her team has discovered that around half of people with the MOG antibody have optic neuritis, and the other half have a range of other neurological conditions or diseases. Dr Brilot-Turville is investigating whether the presence of MOG (myelin oligodendrocyte glycoprotein) antibodies in the blood can be used to diagnose whether patients has optic neuritis or MS associated optic neuritis. However, not everyone who has optic neuritis will go on to develop MS. Optic neuritis or inflammation of the optic nerve is a common feature of MS. The detection of MOG antibody will help us to provide a better treatment to reduce the attacks, and therefore save the vision of these patients. She will also explore how this antibody is involved in optic neuritis. From the blood of these people, Dr Brilot-Turville’s team will identify children and adults with the MOG antibody. They have shown that this MOG antibody can lead to damage of the insulation on the optic nerve.ĭr Brilot-Turville’s study is a nationwide study of children and adults with optic neuritis at a high risk of blindness. This antibody attacks a protein called myelin oligodendrocyte glycoprotein (MOG), an important protein on the insulation layer of the optic nerve. Recurrent attacks of inflammation on or around the optic nerve can lead to blindness.ĭr Fabienne Brilot-Turville and Associate Professor Dale have recently found an antibody in the blood of children and adults with optic neuritis (inflammation of the optic nerve). Demyelination often also occurs around the optic nerve in people with MS, resulting in vision problems. The International MS Genetics ConsortiumĪ characteristic of MS is demyelination, or loss of myelin around the nerve cells of the brain and spinal cord.Vitamin D MS Prevention Trial – PrevANZ.These reagents are now offered in bundles with MOG Antibody (D-10) ( see ordering information below). m-IgG Fc BP-HRP and m-IgG 2a BP-HRP are the preferred secondary detection reagents for MOG Antibody (D-10) for WB and IHC(P) applications.Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of MOG (D-10): sc-166172.also available conjugated to Alexa Fluor ® 680 or Alexa Fluor ® 790 for WB (NIR), IF and FCM for use with Near-Infrared (NIR) detection systems, such as LI-COR ®Odyssey ®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems.also available conjugated to Alexa Fluor ® 488, Alexa Fluor ® 546, Alexa Fluor ® 594 or Alexa Fluor ® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems.Anti-MOG Antibody (D-10) is available conjugated to agarose for IP HRP for WB, IHC(P) and ELISA and to either phycoerythrin or FITC for IF, IHC(P) and FCM.Anti-MOG Antibody (D-10) is recommended for detection of MOG of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA.raised against amino acids 176-247 mapping at the C-terminus of MOG of human origin.MOG Antibody (D-10) is a mouse monoclonal IgG 2a κ, cited in 9 publications, provided at 200 µg/ml.NITROCELLULOSE, PVDF AND NYLON MEMBRANES.AUTORADIOGRAPHY FILM, TAPE AND PLASTIC WRAP. ![]() Biologically Active Proteins & Peptides.NUCLEOTIDES, PEPTIDES, PROTEINS & AMINO ACIDS.BIOLOGICALLY ACTIVE & PURIFIED PROTEINS.PROTEIN A, G-PLUS & L AGAROSE IP REAGENTS.ISOTYPE SPECIFIC MOUSE IgG BINDING PROTEINS.POLYCLONAL GOAT/RABBIT ANTI-MOUSE SECONDARY ANTIBODIES.MONOCLONAL MOUSE ANTI-RABBIT/GOAT SECONDARY ANTIBODIES.
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